A Phase I Study of S1based Concurrent Chemoradiotherapy Biology Diagrams Cell cycle phase non-specific (CCPNS) drugs Chemotherapy drug mechanisms are generally divided into two categories: Order of administration Act as specific phases within the cell cycle. They are selectively potent if given when a large number of cancer cells are in the appropriate phase of the cell cycle. E.g. antimetabolites such as
Repeat doses of chemotherapy may be given to keep killing cancer cells. Cell-Cycle Specific Chemotherapy. These attack cancer cells during specific phases of the cell cycle, but never during the resting phase. These are often given more than once. This gives the chemotherapy the best chance to kill as many cells as possible. Principles of Clinical Cancer Chemotherapy and Drug Resistance. Cancer Mortality: 2000 = 553,091; Est.2003 = 556,500 Cancer Chemotherapy -- Effectiveness by Disease. Cell Cycle Active, S Phase Specific. ANTIMETABOLITES. Mechanisms. incorporation of nucleotide analog in DNA or RNA, resulting in abnormal nucleic acids Cell cycle-specific chemotherapy drugs are a type of chemotherapy drugs that kill cancer cells during their proliferation. There are two types of cell cycle-specific chemotherapy drugs. They are antimetabolites and plant alkaloids. Antimetabolites. Antimetabolites replace the natural substances used by the cancer cells to divide.
PDF CHAPTER 3 Principles of chemotherapy Biology Diagrams
TABLE 1: Cell-cycle-phase-specific drugs S phase-dependent M phase-dependent Antimetabolites Vinca alkaloids a Capecitabine Vinblastine Cytarabine Vincristine chemotherapy drugs. It can be safely and conveniently adminis-tered with full doses of paclitaxel, doxorubicin, and vinorelbine with no compromise of pharmacokinet-
A special note to the reader: all the chemotherapy drugs discussed herein can be found on OncoLink Rx.. History of chemotherapy. Chemotherapy, or the use of chemical agents to destroy cancer cells, is a mainstay in the treatment of malignancies.The possible role in treating illness was discovered when the bone marrow suppressive effect of nitrogen mustard was noted in the early 1900's.
The Influence of Cell Cycle Regulation on Chemotherapy Biology Diagrams
The cell cycle has four stages: mitosis, gap-1, synthesis phase (S-phase) and gap-2. DNA synthesis occurs in S-phase, chromosomes then align, separate, and cell division takes place during mitosis. Chemotherapy drugs cause cell death by apoptosis, either by directly interfering with DNA, or by targeting the key proteins required for cell division.
